大学化学 >> 2016, Vol. 31 >> Issue (7): 1-13.doi: 10.3866/PKU.DXHX201512007

今日化学 上一篇    下一篇

钆类造影剂的研究进展

段二月,马建功,程鹏*()   

  • 发布日期:2016-07-26
  • 通讯作者: 程鹏 E-mail:pcheng@nankai.edu.cn
  • 基金资助:
    国家基础科学人才培养基金(J1103306)

Advances in Gadolinium(Ⅲ) Chelates as MRI Contrast Agents

Er-Yue DUAN,Jian-Gong MA,Peng CHENG*()   

  • Published:2016-07-26
  • Contact: Peng CHENG E-mail:pcheng@nankai.edu.cn
  • Supported by:
    国家基础科学人才培养基金(J1103306)

摘要:

从钆螯合物造影剂的原理、条件、研究进展、以及提高其弛豫效率的方法4个方面进行介绍与总结;在研究进展方面,着重介绍了荧光、生物敏感造影剂;并且从酶活性、金属离子活性、pH活性3个方面对生物敏感造影剂进行了论述。

关键词: 钆造影剂, 原理, 弛豫效率, 生物活性, 荧光探针

Abstract:

In this paper, the Gd(Ⅲ)-based contrast agents are reviewed from four aspects as followed:principles, conditions, research progresses and approaches for improving relaxivity. The research progresses in the fields of fluorescent and biological contrast agents are deeply introduced. Moreover, the activity of enzyme, pH and metal ions of biological contrast agents are discussed.

Key words: Gd(Ⅲ)-based contrast agents, Principles, Relaxivity, Biological activity, Fluorescent sensor

MSC2000: 

  • O614.33