大学化学 >> 2017, Vol. 32 >> Issue (4): 1-10.doi: 10.3866/PKU.DXHX201702002

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RNA表观遗传修饰——N6-甲基腺嘌呤与植物的生长发育

魏连环,贾桂芳*()   

  • 发布日期:2017-04-20
  • 通讯作者: 贾桂芳 E-mail:guifangjia@pku.edu.cn
  • 基金资助:
    国家重点研发计划“精准医学研究”重点专项(2016YFC0900300)

Epitranscriptomic Modification-N6-Methyladenosine (m6A) and Plant Development

Lian-Huan WEI,Gui-Fang JIA*()   

  • Published:2017-04-20
  • Contact: Gui-Fang JIA E-mail:guifangjia@pku.edu.cn
  • Supported by:
    国家重点研发计划“精准医学研究”重点专项(2016YFC0900300)

摘要:

RNA表观遗传修饰N6-甲基腺嘌呤(m6A)是真核生物信使RNA(mRNA)上存在的最为广泛的中间化学修饰。它在哺乳动物中存在较为广泛,证实m6A为mRNA上的动态可逆化修饰,它由甲基转移酶复合物(编码器)催化形成,同时可以被去甲基酶(消码器)氧化去甲基;m6A可以被结合蛋白(读码器)识别,进而调控mRNA的剪接、稳定性、翻译、出核等。相较之下,m6A在植物中的研究较少。本文将简要回顾目前m6A的研究进展,重点综述m6A在植物中的研究结果,展望m6A在植物生长发育和应对外界刺激时的潜在重要功能。

关键词: N6-甲基腺嘌呤(m6A), RNA表观遗传学, m6A甲基转移酶, m6A去甲基酶, m6A结合蛋白

Abstract:

Epitranscriptomic modification-N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic mRNA. m6A has been well studied in mammals and proved to be dynamic and reversible. In mammals, it is installed by the m6Amethyltransferase complex (writers) and can be reversed by demethylases (erasers); it can be recognized by m6A-binding proteins (readers) to regulate RNA processing, such as splicing, stability, translation efficiency, nuclear export and so on. However, the research of m6A in plants is less limited. Here we summarize the latest progresses of m6A, especially m6A study in plants, and further discuss the potential impacts of m6A on plant growth and development, and responses to external stimuli.

Key words: N6-Methyladenosine (m6A), Epitranscriptome, m6A Methyltransferase, m6A Demethylase, m6A Binding protein

MSC2000: 

  • G64