大学化学 >> 2018, Vol. 33 >> Issue (3): 1-10.doi: 10.3866/PKU.DXHX201711038

今日化学 上一篇    下一篇

核药物发展小记

李聪2,刘慧1,韩宇翔1,刘志博1,2,*()   

  1. 1 北京大学化学与分子工程学院, 北京 100871
    2 北京大学前沿交叉学科研究院, 清华大学-北京大学生命科学联合中心, 北京 100871
  • 收稿日期:2017-11-30 发布日期:2018-03-13
  • 通讯作者: 刘志博 E-mail:zbliu@pku.edu.cn
  • 基金资助:
    国家自然科学基金(21778003)

Nuclear Medicine: The Synergy of Radiochemistry and Molecular Medicine

Cong LI2,Hui LIU1,Yuxiang HAN1,Zhibo LIU1,2,*()   

  1. 1 College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China
    2 Tsinghua University-Peking University Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, P. R. China
  • Received:2017-11-30 Published:2018-03-13
  • Contact: Zhibo LIU E-mail:zbliu@pku.edu.cn
  • Supported by:
    国家自然科学基金(21778003)

摘要:

简要回顾了20世纪70年代以来核药物领域发展的主要成就,并对目前在临床上应用最为广泛的核药物探针[18F]FDG作了重点介绍。[18F]FDG的发展可追溯至20世纪20年代,历经半个世纪终于成功应用于临床,在肿瘤、神经退行性疾病、心血管疾病的诊断中发挥了巨大作用。除此以外,本文也介绍了多肽类及蛋白类核药物的最新进展。在梳理核药物发展脉络的同时,本文也借此机会向读者介绍了几位为核药物发展做出巨大贡献的科学家,并作为晚辈向其致以崇高的敬意。最终,笔者希望向读者阐明核药物研究立足基础研究、面向临床问题的学科特色,也希望读者能通过对经典核药物发展脉络的了解,对自身的科学研究有所启发。

关键词: 核药物, 正电子发射断层扫描成像, 应用化学

Abstract:

The major progresses of nuclear medicine since 1970s are briefly reviewed. This mini-review is mainly focused on the development of [18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG), which is the most widely applied PET tracer in clinic diagnosis. The investigation of [18F]FDG dated back to 1920s and was finally applied to the clinic after almost half century. [18F]FDG has been of great importance in the diagnosis of tumor, neurodegenerative diseases and cardiovascular diseases ever since. Except from [18F]FDG, the state-of-art development in peptide and protein nuclear medicines is also introduced. Along with the course of the development of nuclear medicine, several scientists who have made a great contribution to nuclear medicine are also introduced and paid at the same time with our sincere respect. With these introductions above, the authors intend to demonstrate the unique characteristic of nuclear medicine based on basic research and oriented to clinic problems. At last, the authors sincerely hope that the readers could be inspired on their own scientific researches after getting an insight into the history of classic nuclear medicines.

Key words: Nuclear medicine, Positron emission tomography imaging, Applied chemistry

MSC2000: 

  • G64