大学化学 >> 2018, Vol. 33 >> Issue (6): 26-32.doi: 10.3866/PKU.DXHX201712027

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芳卤化合物的邻位锂化反应和锂卤交换反应

杜成堂*(),张玉斌,赵冬冬,张军,李凯   

  • 收稿日期:2017-12-18 发布日期:2018-06-01
  • 通讯作者: 杜成堂 E-mail:duchengtang2008@163.com

Ortho Lithiation and Lithium-Halogen Exchange of Aromatic Halide

Chengtang DU*(),Yubin ZHANG,Dongdong ZHAO,Jun ZHANG,Kai LI   

  • Received:2017-12-18 Published:2018-06-01
  • Contact: Chengtang DU E-mail:duchengtang2008@163.com

摘要:

介绍了芳卤化合物的邻位锂化反应和锂卤交换反应的反应机制、控制因素及应用实例,并且比较两种反应的异同点,从而使读者能够更好地掌握这两种非常重要的合成方法,并加以灵活运用。

关键词: 芳卤化合物, 邻位锂化, 锂-卤交换, 反应机理

Abstract:

In this paper, the mechanism, influence factor and application examples for ortho lithiation reaction and lithium-halide exchange reaction of aromatic compounds were introduced. The similarities and differences between these two reaction are discussed, so that readers can well master and apply this two important synthesis methods.

Key words: Aromatic halide, Ortho lithiation, Lithium-halogen exchange, Mechanism research

MSC2000: 

  • G64