大学化学 >> 2020, Vol. 35 >> Issue (1): 98-104.doi: 10.3866/PKU.DXHX201904048

化学实验 上一篇    下一篇

苯甲酸、对甲苯胺、乙酰苯胺三组分分离实验教学设计

蒋历辉,陈国辉,王微宏,邹应萍*(),罗一鸣   

  • 收稿日期:2019-04-26 录用日期:2019-08-19 发布日期:2019-09-05
  • 通讯作者: 邹应萍 E-mail:yingpingzou@csu.edu.cn
  • 基金资助:
    国家自然科学基金(21506258);湖南省自然科学基金(2017JJ2325)

Design of Separation Experiment of Three Components of Benzoic Acid, p-Methylaniline and Acetanilide

Lihui Jiang,Guohui Chen,Weihong Wang,Yingping Zou*(),Yiming Luo   

  • Received:2019-04-26 Accepted:2019-08-19 Published:2019-09-05
  • Contact: Yingping Zou E-mail:yingpingzou@csu.edu.cn
  • Supported by:
    国家自然科学基金(21506258);湖南省自然科学基金(2017JJ2325)

摘要:

分离提纯是有机合成中关键的实验步骤,反应后处理这部分的工作内容要占到90%的工作量。为提高学生从混合物中分离目标化合物的实验技能,进一步锻炼学生综合运用萃取、蒸馏、重结晶等纯化实验操作,中南大学化学化工学院有机化学教学组在有机化学实验教学中安排了"三组分混合物分离"实验,面向的学生为医学临床五年制和八年制、化学化工学院的制药工程及应用化学专业。本文详细探讨了该实验的酸、碱分离两种教学方案,对先加酸分离得到的三个组分进行了1H NMR测试。从两个方案的实验教学效果来看,先加酸或先加碱对实验结果没有影响。

关键词: 三组分, 分离提纯, 有机实验教学, 1H NMR测试

Abstract:

Separation and purification is the key step in organic synthesis, which is 90% of the total work. To train undergraduates' laboratory skill of separation and purification from the crude product or mixture and improve their understanding ability of using the theory of extraction, distillation, recrystallization, the "Separation of three organic component mixtures" is arranged by the organic chemistry teaching group at the College of Chemistry and Chemical Engineering, Central South University. Students include the five-year and eight-year medical clinic, pharmaceutical and applied chemistry. In this paper, the two teaching schemes of acid and alkali separation in this experiment are discussed in detail, and the laboratory teaching effects of the two schemes are compared.

Key words: Three components, Separation and purification, Organic laboratory teaching, 1H NMR characterization

MSC2000: 

  • G64