大学化学 >> 2020, Vol. 35 >> Issue (1): 40-46.doi: 10.3866/PKU.DXHX201905024

知识介绍 上一篇    下一篇

抗癌药物的先驱——顺铂

郭世祺,马荔*()   

  • 收稿日期:2019-05-06 录用日期:2019-06-13 发布日期:2019-06-25
  • 通讯作者: 马荔 E-mail:mali@sjtu.edu.cn

The Pioneer of Anticancer Drugs: Cisplatin

Shiqi Guo,Li Ma*()   

  • Received:2019-05-06 Accepted:2019-06-13 Published:2019-06-25
  • Contact: Li Ma E-mail:mali@sjtu.edu.cn

摘要:

顺铂在人类抗癌历程中发挥着里程碑式的作用,本文重点介绍顺铂的作用机理、致毒机理和细胞对其产生耐药性的机理,并由此指出铂类药物所存在的缺陷以及发展方向。

关键词: 顺铂, 作用机理, 致毒机理, 耐药性

Abstract:

This review provides a brief view of the cisplatin's mechanism of action, toxicity and drug resistance of cells, and points out the defects and the developing direction of the anticancer platinum drugs.

Key words: Cisplatin, Mechanism of action, Mechanism of toxication, Drug resistance

MSC2000: 

  • G64