大学化学 >> 2020, Vol. 35 >> Issue (4): 168-172.doi: 10.3866/PKU.DXHX201911037

所属专题: 全国大学生化学实验创新设计竞赛

  上一篇    下一篇

环己酮制备实验的改进

张思雨1, 郝天辉1, 王则月1, 姚赟1, 凌剑1, 赵静峰2,*()   

  1. 1 云南大学化学科学与工程学院, 昆明 650091
    2 云南大学教育部自然资源药物化学重点实验室, 昆明 650091
  • 收稿日期:2019-11-20 录用日期:2019-12-11 发布日期:2019-12-26
  • 通讯作者: 赵静峰 E-mail:jfzhao@ynu.edu.cn
  • 基金资助:
    云南省教改项目(JG2018025)

Improvement of the Cyclohexanone Preparation Experiment

Siyu Zhang1, Tianhui Hao1, Zeyue Wang1, Yun Yao1, Jian Ling1, Jingfeng Zhao2,*()   

  1. 1 School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China
    2 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan University, Kunming 650091, P. R. China
  • Received:2019-11-20 Accepted:2019-12-11 Published:2019-12-26
  • Contact: Jingfeng Zhao E-mail:jfzhao@ynu.edu.cn

摘要:

以环己醇合成环己酮在大学有机化学基础实验教学中占有重要地位,但是目前实验教学主要使用的方法是重铬酸钠-浓硫酸氧化法,使用强腐蚀性的浓硫酸,并产生含铬强酸性有毒废液。本文采用NaClO-TEMPO-TBAB催化氧化反应,缩短实验时间,提高产率并实现了半微型化实验,在达到同样教学目的的同时避免了原有实验带来的铬污染和强酸问题。

关键词: 环己醇, 环己酮, 催化氧化, 相转移催化

Abstract:

The cyclohexanone preparation is an important experiment in fundamental organic chemistry laboratory for college students. In this paper, NaClO-TEMPO-TBAB catalytic oxidation reaction was used to replace chromic acid oxidation reaction, avoiding concentrated sulfuric acid and chromium-containing waste. At the same time, the reaction conditions were optimized to achieve small scale and shorten operating time which can train and improve students' operation skills in the experiment.

Key words: Cyclohexanol, Cyclohexanone, Catalytic oxidation, Phase transfer catalysis

MSC2000: 

  • G64