大学化学 >> 2021, Vol. 36 >> Issue (2): 2002045.doi: 10.3866/PKU.DXHX202002045

化学实验 上一篇    下一篇

“核磁共振法定量测定酚氨咖敏药片中各组分”实验的改进

陈文学(), 刘莎莎, 李会香   

  • 收稿日期:2020-02-20 录用日期:2020-03-30 发布日期:2020-04-09
  • 通讯作者: 陈文学 E-mail:wxchen@fudan.edu.cn
  • 作者简介:陈文学, Email: wxchen@fudan.edu.cn

Improvement of the Determination of Components in Paracetamol, Aminophenazone, Caffeine and Chlorpheniramine Maleate Tablet Using 1H Nuclear Magnetic Resonance Spectroscopy

Wenxue Chen(), Shasha Liu, Huixiang Li   

  • Received:2020-02-20 Accepted:2020-03-30 Published:2020-04-09
  • Contact: Wenxue Chen E-mail:wxchen@fudan.edu.cn

摘要:

基于核磁共振(NMR)技术的定量分析方法在医药领域已有广泛应用。为让学生了解NMR谱仪的工作原理,掌握基于NMR技术的药物定量分析方法,本文对教学实验“核磁共振法定量测定酚氨咖敏药片中各组分”进行了改进:优化样品处理条件,增加微量组分马来酸氯苯那敏的含量测定。发现在室温下即可实现药片中四种组分含量的准确测定。

关键词: 核磁共振, 定量分析, 酚氨咖敏药片

Abstract:

The quantitative analysis based on nuclear magnetic resonance (NMR) spectroscopy has been widely applied to medical researches. In order to help students to learn more about the basic working principle of NMR spectrometer and the method of quantitative analysis of the drugs using NMR spectroscopy, two improvements were made about "the determination of components in paracetamol, aminophenazone, caffeine and chlorpheniramine maleate tablet using 1H NMR spectroscopy" experimentby optimizing the procedure for sample treatment and introducing the determination of the trace component (e.g., chlorpheniramine maleate) in the tablets. the content of four components in tablets could be simultaneously analyzed under mild conditions.

Key words: Nuclear magnetic resonance (NMR), Quantitative analysis, Paracetamol, aminophenazone, caffeine and chlorpheniramine maleate tablet (PACC)

MSC2000: 

  • G64