大学化学 >> 2021, Vol. 36 >> Issue (4): 2005028.doi: 10.3866/PKU.DXHX202005028

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端炔的硼化-迁移加成-氧化和硼化-氧化

杨占会(), 陈洋   

  • 收稿日期:2020-05-11 录用日期:2020-06-22 发布日期:2020-07-06
  • 通讯作者: 杨占会 E-mail:zhyang@mail.buct.edu.cn
  • 作者简介:杨占会, Email: zhyang@mail.buct.edu.cn
  • 基金资助:
    北京市自然科学基金(2202041);国家自然科学基金(21602010)

The Boration-Migratory Addtion-Oxidation and Boration-Oxidation of 1-Alkynes

Zhanhui Yang(), Yang Chen   

  • Received:2020-05-11 Accepted:2020-06-22 Published:2020-07-06
  • Contact: Zhanhui Yang E-mail:zhyang@mail.buct.edu.cn

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摘要：

端炔的硼氢化-氧化是基础有机化学授课的重要内容。本文在此基础上，介绍端炔的硼化-迁移加成-氧化和硼化-氧化。前一类反应可将端炔转化为醛，后两类则转化为酮、羧酸、酯和酰胺。本文所涉及内容与基础有机化学知识密切结合，又有一定程度的拔高。教师同时讲授三类反应，可丰富学生的知识积累，提高学生的认知能力。

关键词: 端炔, 硼氢化, 硼化, 迁移加成, 氧化

Abstract:

The hydroboration-oxidation of 1-alkynes is important in fundamental organic chemistry. As an extension, this paper introduces the boration-migratory addtion-oxidation and boration-oxidation of 1-alkynes, which are closely related to yet more advanced than the knowledge of fundamental organic chemistry. The former one reaction converts 1-alkynes to aldehydes, while the latter two to ketones, caroboxylic acids, esters, and amides. Teaching these three types of reactions is helpful to improve the students' knowledge reserves and cognitive ability.

Key words: 1-Alkyne, Hydroboration, Boration, Migratory addition, Oxidation

MSC2000: 

  • G64