大学化学 >> 2020, Vol. 35 >> Issue (12): 247-260.doi: 10.3866/PKU.DXHX202006022

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生化教材中存在44年的瑕疵——吡啶环上氮原子的化合价

高琨()   

  • 收稿日期:2020-06-04 录用日期:2020-08-02 发布日期:2020-09-01
  • 通讯作者: 高琨 E-mail:kgao@xjtu.edu.cn
  • 作者简介:高琨，Email: kgao@xjtu.edu.cn
  • 基金资助:
    国家自然科学基金(31870983)

Incorrect Interpretations from Biochemical Textbooks for 44 Years in the Case of Valence of Nitrogen Atom in Pyridine Ring

Kun Gao()   

  • Received:2020-06-04 Accepted:2020-08-02 Published:2020-09-01
  • Contact: Kun Gao E-mail:kgao@xjtu.edu.cn

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摘要：

对国内不同版本生物化学教材关于烟酰胺腺嘌呤二核苷酸（NAD+）或磷酸烟酰胺腺嘌呤二核苷酸（NADP+）的氧化还原反应机理解释的一句话，即“尼克酰胺的氮为五价，能接受电子还原成为三价氮”进行剖析，可以看到尼克酰胺吡啶环上的氮原子化合价不是+5价，应该是?3，以此抛砖引玉提高教材质量。

关键词: 烟酰胺腺嘌呤二核苷酸, 磷酸烟酰胺腺嘌呤二核苷酸, 氧化还原, 化合价

Abstract:

Understanding redox reactions in reaction of nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) requires a clear grasp of the textbook content. The reactions in nicotinamide coenzymes with reduced and oxidized forms have been compared in various biochemistry textbooks. Incorrect interpretations usually emphasize the valence changes that at nitrogen in the pyridine ring of a nicotinamide from +5 to +3. Actually, the valence of nitrogen in pyridine ring is -3. We have gathered shreds of evidences and provide here possible suggestions and caution for readers and instructors.

Key words: Nicotinamide adenine dinucleotide, Nicotinamide adenine dinucleotide phosphate, Oxidation and reduction, Valence

MSC2000: 

  • G64