大学化学 >> 2021, Vol. 36 >> Issue (8): 2010054.doi: 10.3866/PKU.DXHX202010054

化学实验 上一篇    下一篇

阿司匹林水解反应动力学参数测定实验的改进

张胜红, 戚传松, 荣华, 龚良发, 李巍()   

  • 收稿日期:2020-10-23 录用日期:2020-11-19 发布日期:2020-12-30
  • 通讯作者: 李巍 E-mail:liwei77@bipt.edu.cn
  • 作者简介:李巍, Email: liwei77@bipt.edu.cn
  • 基金资助:
    北京石油化工学院教育教学改革研究项目(ZD20160101)

Improving Kinetic Measurements of Aspirin Hydrolysis

Shenghong Zhang, Chuansong Qi, Hua Rong, Liangfa Gong, Wei Li()   

  • Received:2020-10-23 Accepted:2020-11-19 Published:2020-12-30
  • Contact: Wei Li E-mail:liwei77@bipt.edu.cn

摘要:

阿司匹林水解反应动力学是药学、医学类专业物理化学理论教学中的典型案例,其动力学参数的测定通常采用络合显色法,存在实验步骤繁琐且耗时过长等问题,难以转化为物理化学实验教学内容。为解决上述问题,改进了紫外分光光度法测定阿司匹林水解反应动力学的方法并详细探讨了其实验原理。和络合显色法相比,新方案大幅简化了实验内容和步骤,避免了含酸废液的产生并将反应时间缩短为4小时。改进后的实验项目有望发展为药学和医学类专业的化学动力学教学实验。

关键词: 阿司匹林, 乙酰水杨酸, 水解, 动力学, 分光光度法

Abstract:

The kinetics of aspirin hydrolysis is the critical content of theoretical physical chemistry for both medical and pharmaceutical students. The experiment is usually conducted by monitoring aspirin's hydrolysis product (salicylic acid, SA) with a spectrophotometer after reaction with soluble Fe3+ salts. However, the kinetic measurement of aspirin hydrolysis has not been widely implemented in physical chemistry laboratory, because of the complicated procedures and the long testing period required to perform the reaction. In this work, the ultraviolet absorbance of SA at a wavelength of 296 nm has been employed to determine the kinetics of aspirin hydrolysis in a phosphate buffer (pH = 6.85). Compared with the traditional method, these improvements simplify the experimental procedures significantly, avoid the formation of liquid acidic wastes, and shorten the reaction time, thus, turn the hydrolysis of aspirin into a practical kinetic experiment for medical and pharmaceutical college students.

Key words: Aspirin, Acetylsalicylic acid, Hydrolysis, Kinetics, Spectrophotometry

MSC2000: 

  • G642.0