大学化学 >> 2021, Vol. 36 >> Issue (12): 2103014.doi: 10.3866/PKU.DXHX202103014

化学实验 上一篇    下一篇

非那西丁的合成与复方阿司匹林的主成分分析——推荐一个有机化学实验

胡水1, 赖瑢1, 李厚金1, 朱可佳1, 周磊1, 邵光1,2,*()   

  1. 1 中山大学化学学院, 广州 510275
    2 中山大学化学工程与技术学院, 广东 珠海 519082
  • 收稿日期:2021-03-08 录用日期:2021-05-03 发布日期:2021-05-12
  • 通讯作者: 邵光 E-mail:shaog@mail.sysu.edu.cn
  • 作者简介:邵光, Email: shaog@mail.sysu.edu.cn
  • 基金资助:
    2020年中山大学本科教学质量工程项目(31000-31911100)

Synthesis of Phenacetin and Principal Component Analysis of Compound Aspirin: An Organic Chemistry Experiment

Shui Hu1, Rong Lai1, Houjin Li1, Kejia Zhu1, Lei Zhou1, Guang Shao1,2,*()   

  1. 1 School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
    2 School of Chemistry Engineering and Technology, Sun Yat-Sen University, Zhuhai 519082, Guangdong Province, China
  • Received:2021-03-08 Accepted:2021-05-03 Published:2021-05-12
  • Contact: Guang Shao E-mail:shaog@mail.sysu.edu.cn

摘要:

以对氨基苯乙醚为原料,与乙酸成盐提高溶解度与反应活性,再与乙酸酐发生亲核取代反应,两步制备非那西丁。以核磁共振氢谱对化合物结构进行解析,并且利用薄层色谱和高效液相色谱对复方阿司匹林中的有效成分进行分析,讨论了色谱技术之间的区别与联系。本实验内容包括加热回流、离心、重结晶、核磁共振波谱以及薄层色谱和高效液相色谱的应用,有利于培养学生的综合分析问题能力。

关键词: 非那西丁, 复方阿司匹林, 薄层色谱, 高效液相色谱

Abstract:

First, p-phenetidine and acetic acid were used as starting materials, and then acetic anhydride was added through nucleophilic substitution reaction to obtain phenacetin. The structure was identified by 1H-NMR. The components of compound aspirin were analyzed by thin layer chromatography and high performance liquid chromatography, and then the relations and differences between the two chromatography techniques were discussed. This experiment covers the experimental skills such as reflux, centrifugation, recrystallization, NMR, thin layer chromatography and high performance liquid chromatography, and can help the undergraduates improve their analytical abilities.

Key words: Phenacetin, Compound aspirin, Thin layer chromatography, High performance liquid chromatography

MSC2000: 

  • G64