大学化学 >> 2022, Vol. 37 >> Issue (7): 2109021.doi: 10.3866/PKU.DXHX202109021

化学实验 上一篇    下一篇

基于流动化学平台的3-(2-羟基苯基)-1-(吡啶-3-基)丙-2-烯-1-酮合成实验改进

王文权, 刘萌, 孙康, 刘智峰, 季晓晖, 刘全()   

  • 收稿日期:2021-09-06 录用日期:2021-11-05 发布日期:2021-12-10
  • 通讯作者: 刘全 E-mail:liuq@snut.edu.cn
  • 作者简介:刘全, Email: liuq@snut.edu.cn
  • 基金资助:
    陕西理工大学大创项目;陕西理工大学研究生教育改革项目

Improvement of the 3-(2-Hydroxyphenyl)-1-(Pyridin-3-Yl)Prop-2-En-1-One Synthesis Experiment Based on Flow Chemistry Platform

Wenquan Wang, Meng Liu, Kang Sun, Zhifeng Liu, Xiaohui Ji, Quan Liu()   

  • Received:2021-09-06 Accepted:2021-11-05 Published:2021-12-10
  • Contact: Quan Liu E-mail:liuq@snut.edu.cn

摘要:

流动化学技术相较于传统间歇式反应,具有高传热与传质效率、高反应安全性、短反应时间以及可精准控制反应参数等优点,从而成为有机合成中最具潜力的技术之一。国外多所高校已经开设流动化学相关课程实验,而我国相关课程实验仍处于起步阶段。本实验将传统有机实验中Claisen-Schmidt反应合成查尔酮衍生物进行改进,通过搭建液相-液相流动化学反应平台进行流动化学合成,并通过紫外-可见光谱仪对反应过程进行监测。该实验在实现相同教学目的下,具有反应时间短、现象明显、碱用量少等显著优势。

关键词: 流动化学, Claisen-Schmidt反应, 查尔酮衍生物, 合成

Abstract:

Flow chemistry technology has become one of the most promising technologies in organic synthesis due to its high heat and mass transfer efficiency, high reaction safety, short reaction time and precise control of reaction parameters compared with conventional batch reaction. Many universities abroad have set up the experiment of flow chemistry, while it is still in its infancy in China. In this study, the classic Claisen-Schmidt reaction in organic chemistry experiment was improved through the liquid-liquid flow chemical reaction platform. The reaction process was monitored by UV-Vis Spectrophotometry. Under the same teaching purpose, this experiment has the distinct advantages of short reaction time, obvious phenomenon and less alkali dosage.

Key words: Flow Chemistry, Claisen-Schmidt reaction, Chalcone derivative, Synthesis

MSC2000: 

  • G64