大学化学 >> 2016, Vol. 31 >> Issue (10): 98-104.doi: 10.3866/PKU.DXHX201602011

国外化学教育 上一篇    下一篇

浅谈国外“Suzuki-Miyaura金属偶联反应”的教学设计思路

李田,马锴果,高珍,李维红*()   

  • 发布日期:2016-11-02
  • 通讯作者: 李维红 E-mail:litian@pku.edu.cn

A Brief Introduction to Suzuki-Miyaura Coupling Reaction in Organic Lab Abroad

Tian LI,Kai-Guo MA,Zhen GAO,Wei-Hong LI*()   

  • Published:2016-11-02
  • Contact: Wei-Hong LI E-mail:litian@pku.edu.cn

摘要:

Suzuki-Miyaura金属偶联反应是在零价钯配合物的催化下,芳基硼酸或硼酸酯与卤代芳烃发生交叉偶联的过程。该反应具有很强的底物适应性和官能团容忍性,广泛应用于众多天然产物与有机材料的合成。鉴于反应的重要性,近年来国外高校逐渐尝试将Suzuki-Miyaura反应引入到本科生的有机实验教学中。本文针对2000年后Journal of Chemical Education期刊中涉及的Suzuki-Miyaura反应,分别从反应条件、后处理和表征方法、实验拓展等多个方面进行了比较和归纳,并对其设计理念和教学特色进行了综述。

关键词: Suzuki-Miyaura金属偶联反应, 教学实验设计

Abstract:

Suzuki-Miyaura reaction is a coupling process of aryl boric acid (boron ester) and aryl halide that catalyzed by palladium (0).The reaction shows well tolerance for various functional groups and is wildly applied in syntheses of natural products and organic materials.Recently,colleges abroad tried to introduce this reaction into the undergraduate organic lab.This paper collected the literatures in Journal of Chemical Education about the Suzuki-Miyaura reaction since 2000 and gave an overview.

Key words: Suzuki-Miyaura coupling reaction, Experimental design

MSC2000: 

  • G64