大学化学 >> 2019, Vol. 34 >> Issue (6): 53-59.doi: 10.3866/PKU.DXHX201811009

化学实验 上一篇    下一篇

肉桂酸的逆合成分析、合成设计及实验制备——一次设计型实验课的探索

郑媛*(),兰泉,查正根   

  • 收稿日期:2018-11-12 录用日期:2019-01-24 发布日期:2019-02-25
  • 通讯作者: 郑媛 E-mail:zgzha@ustc.edu.cn
  • 基金资助:
    化学国家级实验教学示范中心建设项目;省级有机化学实验教学团队项目(2016)

An Exploration of the Design-Oriented Experiments: The Retrosynthetic Analysis, Design and Preparation of Cinnamic Acid

Yuan ZHENG*(),Quan LAN,Zhenggen ZHA   

  • Received:2018-11-12 Accepted:2019-01-24 Published:2019-02-25
  • Contact: Yuan ZHENG E-mail:zgzha@ustc.edu.cn
  • Supported by:
    化学国家级实验教学示范中心建设项目;省级有机化学实验教学团队项目(2016)

摘要:

以肉桂酸为目标产物,通过逆合成分析、合成设计,采用不同的实验方法合成制备,介绍了水相Heck反应、无溶剂Perkin反应、水相Wittig反应、水相Knoevenagel反应,拓展了学生的合成设计思维。本实验涵盖了目标产物的合成、纯化与表征,让学生认识和完成了一个基本的科研过程,提高了学生的综合能力。

关键词: Heck反应, Perkin反应, Wittig反应, Knoevenagel反应, 肉桂酸, 设计型实验, 逆合成分析

Abstract:

This article focuses on the synthesis of cinnamic acid. Retrosynthetic analysis and synthetic design have shown that the construction of cinnamic acid can be achieved by several protocols, including the aqueous Heck reaction, the solvent-free Perkin reaction, the aqueous Wittig reaction and the aqueous Knoevenagel reaction. These protocols extend the synthetic design thinking of students. These experiments cover the synthesis, purification and characterization of cinnamic acid, helping students understand and complete a basis scientific research process; thus, students' comprehensive ability is improved.

Key words: Heck reaction, Perkin reaction, Wittig reaction, Knoevenagel reaction, Cinnamic acid, Designing experiment, Retrosynthesis analysis

MSC2000: 

  • G64