大学化学 >> 2020, Vol. 35 >> Issue (12): 2-8.doi: 10.3866/PKU.DXHX202008080

所属专题: 科学抗疫中的化学

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新冠病毒刺突蛋白及其受体的结构与相互作用

杨海龙1,2, 刘允2, 杨斌1,*()   

  1. 1 广州医科大学基础医学院生物医学工程系, 广州 511436
    2 广东医科大学药学院, 广东 东莞 523808
  • 收稿日期:2020-08-31 录用日期:2020-10-15 发布日期:2020-10-30
  • 通讯作者: 杨斌 E-mail:bin.yang@gzhmu.edu.cn
  • 作者简介:杨斌, Email: bin.yang@gzhmu.edu.cn
  • 基金资助:
    国家自然科学基金(51903062);广东省基础与应用基础研究基金(2020A1515011320)

Structures and Interactions of SARS-CoV-2's Spike Protein and Its Receptor

Hailong Yang1,2, Yun Liu2, Bin Yang1,*()   

  1. 1 Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China
    2 School of Pharmaceutical Sciences, Guangdong Medical University, Dongguan 523808, Guangdong Province, P. R. China
  • Received:2020-08-31 Accepted:2020-10-15 Published:2020-10-30
  • Contact: Bin Yang E-mail:bin.yang@gzhmu.edu.cn

摘要:

生物化学是化学的分支,是研究生命物质的化学组成结构及化学变化的基础生命科学。新冠肺炎是全人类所面临的问题,本文以生物化学的视角,阐述新冠病毒的刺突蛋白及其受体人血管紧张素转化酶2的化学结构及其相互作用,对目前已发表的国内外相关研究进行总结,有望为新冠疫苗的研发提供参考。

关键词: 新型冠状病毒, 刺突蛋白, 血管紧张素转化酶2

Abstract:

Biochemistry is a branch subject of chemistry, which is the study of chemical structures and processes associated with living organisms. COVID-19 pandemic is a problem for human beings. From the perspective of biochemistry, this paper demonstrates the chemical structure and interactions of SARS-CoV-2's spike protein and its receptor (human angiotensin converting enzyme 2), and summarizes the related research progresses. The authors hope to provide insights for the development of COVID-19 vaccine.

Key words: SARS-CoV-2, Spike protein, Angiotensin converting enzyme 2

MSC2000: 

  • G64