大学化学 >> 2022, Vol. 37 >> Issue (3): 2110003.doi: 10.3866/PKU.DXHX202110003

所属专题: 生物无机与大健康

今日化学 上一篇    下一篇

生物合成高能化学物质

陈子鹏1, 赵钰沁2, 王宸1, 王秀秀1, 魏炜2, 赵劲1,*()   

  1. 1 南京大学化学化工学院,南京 210023
    2 南京大学生命科学学院,南京 210023
  • 收稿日期:2021-10-08 录用日期:2021-11-15 发布日期:2021-12-22
  • 通讯作者: 赵劲 E-mail:jingzhao@nju.edu.cn
  • 作者简介:赵劲, Email: jingzhao@nju.edu.cn
  • 基金资助:
    国家自然科学基金杰出青年科学基金(22025701);国家自然科学基金面上项目(22177048);国家重点研发计划合成生物学专项子课题(2019YFA0905801)

Biosynthesis of High-Energy Chemicals

Zipeng Chen1, Yuqin Zhao2, Chen Wang1, Xiuxiu Wang1, Wei Wei2, Jing Zhao1,*()   

  1. 1 School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
    2 School of Life Sciences, Nanjing University, Nanjing 210023, China
  • Received:2021-10-08 Accepted:2021-11-15 Published:2021-12-22
  • Contact: Jing Zhao E-mail:jingzhao@nju.edu.cn

摘要:

从分子到细胞,从个体到社会,能量的需求和转化无处不在。探索高能物质的合成与利用,具有较重要的科学意义和应用价值。目前高能物质的化学合成通常污染较大、耗能较高,且往往副产物较多,难以分离纯化。相较于传统的化学合成方法,生物合成具有绿色环保和高效利用清洁能源等特点,是符合国家“碳中和”目标的新型合成路径。高能物质的生物合成,将是未来的迅速发展方向之一。本文将从能源物质、含能材料和天然高能物质三个方面,选取四种代表性高能物质,介绍其生物合成途径及与之相关的关键金属酶。

关键词: 高能物质, 生物合成, 氢气, 氧化偶氮键, 丁三醇, 多聚磷酸盐

Abstract:

From molecules to cells, the energy demand is ubiquitous in our society. Synthesis and utilization of high-energy chemicals is a major challenge scientifically and economically. The current chemical synthesis of high-energy compounds often generates pollution and consumes a lot of energy. With the existence of by-products, it's hard to separate target products. Compared to chemical synthesis, biosynthesis is considered environmentally friendly and cost-effective energy, and is in accord with the Carbon Neutralization goal. Biosynthesis of high-energy chemicals is one of the fastest growing fields. This article will choose 4 chemicals, in terms of energy source, energetic materials and bio-high-energy compounds, to briefly introduce the correspondent biosynthesis pathway and key metalloenzyme.

Key words: High-energy chemicals, Biosynthesis, Hydrogen, Azoxy bond, Butane-1, 2, 4-triol, Polyphosphate

MSC2000: 

  • G64