大学化学 >> 2022, Vol. 37 >> Issue (3): 2111005.doi: 10.3866/PKU.DXHX202111005

所属专题: 生物无机与大健康

今日化学 上一篇    下一篇

无机纳米材料在骨代谢调控中的应用

王秋祥1, 刘奕辛1, 葛昆2, 张金超2, 周国强1,2,*()   

  1. 1 河北大学基础医学院,河北 保定 071000
    2 河北大学化学与环境科学学院,河北 保定 071002
  • 收稿日期:2021-11-01 录用日期:2021-11-29 发布日期:2021-12-30
  • 通讯作者: 周国强 E-mail:zhougq1982@163.com
  • 作者简介:周国强,Email: zhougq1982@163.com
    第一联系人:

    共同第一作者,对本工作有同等贡献

  • 基金资助:
    河北省自然科学基金(B2021201045);河北省自然科学基金(B2020201020);河北省研究生示范课程建设项目(KCJSX2020004)

Inorganic Nanomaterials for Bone Metabolism Regulation

Qiuxiang Wang1, Yixin Liu1, Kun Ge2, Jinchao Zhang2, Guoqiang Zhou1,2,*()   

  1. 1 School of Basic Medical Sciences, Hebei University, Baoding 071000, Hebei Province, China
    2 College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei Province, China
  • Received:2021-11-01 Accepted:2021-11-29 Published:2021-12-30
  • Contact: Guoqiang Zhou E-mail:zhougq1982@163.com

摘要:

与有机和高分子纳米材料相比,无机纳米材料具有化学性质稳定、力学性能优良、生物相容性和骨诱导性良好等优势,是用于骨代谢调控的主要材料。文章分别从细胞、分子及动物水平总结了羟基磷灰石、稀土纳米材料、金纳米颗粒、碳纳米管等无机纳米材料在骨代谢调控中的作用及其机制,并对无机纳米材料在骨代谢调控中面临的挑战进行了展望。

关键词: 羟基磷灰石, 稀土纳米材料, 金纳米颗粒, 碳纳米管, 骨代谢

Abstract:

Compared with organic and polymeric nanomaterials, inorganic nanomaterials have the advantages of stable chemical properties, good mechanical properties, excellent biocompatibility, and osteoinductive properties. Inorganic nanomaterials are commonly used as the main material in the regulation of bone metabolism. Herein, the roles and mechanisms of inorganic nanomaterials (such as hydroxyapatite, rare earth nanomaterials, gold nanoparticles, and carbon nanotubes) in the regulation of bone metabolism on the cellular, molecular, and animal levels are summarized. The challenges faced during the application of inorganic nanomaterials toward the regulation of bone metabolism are also presented.

Key words: Hydroxyapatite, Rare earth nanomaterials, Gold nanoparticles, Carbon nanotubes, Bone metabolism

MSC2000: 

  • G64