大学化学 >> 2017, Vol. 32 >> Issue (2): 89-97.doi: 10.3866/PKU.DXHX201605023

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浅析协同效应的理论模型与应用拓展

梁妍钰1,3,王志鹏1,2,*()   

  1. 1 清华大学化学系, 北京 100084
    2 Department of Chemistry, Texas A & M University, Texas 77840, USA
    3 Computational Biology Department, Carnegie Mellon University, Pennsylvania 15213, USA
  • 发布日期:2017-02-11
  • 通讯作者: 王志鹏 E-mail:wzpchem1991@gmail.com

Discussion on the Theoretical Models and Practical Applications of Cooperative Effects

Yan-Yu LIANG1,3,Zhi-Peng WANG1,2,*()   

  1. 1 Chemistry Department, Tsinghua University, Beijing 100084, P. R. China
    2 Department of Chemistry, Texas A & M University, Texas 77840, USA
    3 Computational Biology Department, Carnegie Mellon University, Pennsylvania 15213, USA
  • Published:2017-02-11
  • Contact: Zhi-Peng WANG E-mail:wzpchem1991@gmail.com

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摘要：

从基础物理化学分析入手，结合生物化学、生物无机化学、酶学和超分子化学等多学科实例，对协同效应的原理和应用进行系统性的全面阐述。以期对教学与相关科研有帮助。

关键词: 协同效应, "S"型曲线, 希尔方程, 血红蛋白, 生物素

Abstract:

This manuscript introducing "Cooperative Effect" starts from the fundamental physical chemistry principles, followed by the analysis of the mathematical models and the potential applications in combination with case studies from biochemistry, bioinorganic chemistry, enzymology, and supermolecular chemistry. We hope that the review can provide some help for the current fundamental education and research on route.

Key words: Cooperative effect, "S"-Shaped curve, Hill's equation, Hemoglobin, Biotin

MSC2000: 

  • G64