大学化学 >> 2019, Vol. 34 >> Issue (8): 47-50.doi: 10.3866/PKU.DXHX201905013

所属专题: 化学科普(2019)

科普 上一篇    下一篇

钌宝宝的自荐信——我是抗癌小战士

马文,贾卫国*()   

  • 收稿日期:2019-05-06 录用日期:2019-05-27 发布日期:2019-07-15
  • 通讯作者: 贾卫国 E-mail:wgjiasy@ahnu.edu.cn
  • 基金资助:
    国家自然科学基金(21102004)

Self-Recommendation Letter of Baby Ruthenium: I Am an Anticancer Warrior

Wen MA,Weiguo JIA*()   

  • Received:2019-05-06 Accepted:2019-05-27 Published:2019-07-15
  • Contact: Weiguo JIA E-mail:wgjiasy@ahnu.edu.cn
  • Supported by:
    国家自然科学基金(21102004)

摘要:

采取拟人化的手法,以第一人称介绍了钌元素的发现历史,重点阐述了钌配位化合物在抗肿瘤药物方面的应用。详细介绍了在临床或已经进行临床试验的抗肿瘤试剂如KP1019等,以及具有半夹心钌结构的配位化合物及钌多吡啶类的药物。

关键词: 钌, 配合物, 抗癌

Abstract:

Using the anthropomorphic approach, this article introduces the discovery history of ruthenium elements in the first person role, and focuses on the ruthenium complexes as important therapeutic agents for cancer treatment. We have focused our attention on KP1019 incorporating ruthenium ions complexes which have been already used in clinical or have been advanced to clinical trials as anticancer agents. Moreover, the half-sandwich ruthenium and ruthenium polypyridine complexes drugs are also reviewed.

Key words: Ruthenium, Complex, Anticancer

MSC2000: 

  • G64