大学化学 >> 2020, Vol. 35 >> Issue (9): 64-69.doi: 10.3866/PKU.DXHX201909040

知识介绍 上一篇    下一篇

甘氨酸衍生物C(sp3)―H官能团化反应在喹啉类化合物合成中的应用

张元(), 王树涛   

  • 收稿日期:2019-09-25 录用日期:2019-11-27 发布日期:2019-12-02
  • 通讯作者: 张元 E-mail:zhangyuan@lzu.edu.cn

Synthesis of Substituted Quinolines via C(sp3)-H Functionalization of Glycine Derivatives

Yuan Zhang(), Shutao Wang   

  • Received:2019-09-25 Accepted:2019-11-27 Published:2019-12-02
  • Contact: Yuan Zhang E-mail:zhangyuan@lzu.edu.cn

摘要:

C(sp3)―H键官能团化反应被认为是构建C―C键的最直接和高效的合成方法。近年来,通过甘氨酸衍生物C(sp3)―H官能团化反应来合成喹啉类化合物的研究逐渐引起研究者的广泛关注。本文简要介绍了甘氨酸衍生物C(sp3)―H官能团化反应研究现状,并总结了不同催化体系下此类反应在喹啉衍生物合成中的应用,目的在于通过对前沿科研内容的介绍,开拓大学生的知识视野,激发他们对于科学探索的兴趣。

关键词: C(sp3)―H键官能团化, 甘氨酸衍生物, 喹啉

Abstract:

The direct oxidative C(sp3)-H functionalization reaction has long been considered as one of the most efficient and straightforward synthetic protocol for the construction of C-C bonds. Recently, the synthesis of substituted quinolines via C(sp3)-H functionalization of glycine derivatives has gained widespread attention from the chemists. Recent progresses on the C(sp3)-H functionalization of glycine derivatives and their applications in the synthesis of substituted quinolines are described in this paper. The aims are to broaden students' vision and stimulate their interest in scientific research through the introduction of innovative scientific research.

Key words: C(sp3)-H functionalization, Glycine derivatives, Quinolines

MSC2000: 

  • G64