大学化学 >> 2021, Vol. 36 >> Issue (6): 2006030.doi: 10.3866/PKU.DXHX202006030

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“Hofmann-Löffler-Freytag”型反应合成吡咯烷类化合物的研究进展

杨明瑜()   

  • 收稿日期:2020-06-08 录用日期:2020-07-04 发布日期:2020-08-06
  • 通讯作者: 杨明瑜 E-mail:yangmy05@snnu.edu.cn
  • 作者简介:杨明瑜, Email: yangmy05@snnu.edu.cn
  • 基金资助:
    国家自然科学青年基金项目(21602128)

Progress in Synthesis of Pyrrolidine Derivatives by Hofmann-Löffler-Freytag Type Reactions

Mingyu Yang()   

  • Received:2020-06-08 Accepted:2020-07-04 Published:2020-08-06
  • Contact: Mingyu Yang E-mail:yangmy05@snnu.edu.cn

摘要:

含氮杂环化合物广泛存在于天然产物及人工合成的分子中,且表现出很高的生物活性。其中吡咯烷类衍生物是天然产物及药物分子中的特定结构单元,引起了化学家们的广泛关注。发展简洁、高效、普适性强的方法构建该类化合物一直是有机化学家所追求的目标。本文综述了霍夫曼-勒夫勒-弗赖伊塔格(Hofmann-Löffler-Freytag,简称HLF)反应在合成吡咯烷类化合物中的研究进展,内容主要包含两部分:1)卤素介导的HLF型反应;2)无卤素介导的HLF型反应。

关键词: HLF型反应, 吡咯烷衍生物, 卤素介导, 无卤素介导

Abstract:

Nitrogen-containing heterocycles exist widely in natural products, pharmaceuticals and optical materials. These molecules often exhibit high levels of biological and optical activities. Especially, the pyrrolidine derivatives are privileged structural units existed in natural products and pharmaceuticals. Therefore, the development of efficient methods to construct this ubiquitous structure unit is highly desirable. This paper introduces the development of Hofmann-Löffler-Freytag (HLF) reaction in synthesis of pyrrolidine derivatives. The major contents are including two aspects: 1) Halogen-mediated HLF reactions; 2) Non halogen-mediated HLF reactions.

Key words: Hofmann-Löffler-Freytag type reaction, Pyriolidine derivatives, Halogen-mediated, Non halogen-mediated

MSC2000: 

  • G64