大学化学 >> 2021, Vol. 36 >> Issue (12): 2102001.doi: 10.3866/PKU.DXHX202102001

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有机氟化物的电化学合成

张子杭, 李思哲, 阚立言, 温俊, 卞江()   

  • 收稿日期:2021-02-01 录用日期:2021-03-29 发布日期:2021-05-06
  • 通讯作者: 卞江 E-mail:bj@pku.edu.cn
  • 作者简介:卞江,Email: bj@pku.edu.cn
    第一联系人:

    共同第一作者

Electrosynthesis of Organic Fluorides

Zihang Zhang, Sizhe Li, Liyan Kan, Jun Wen, Jiang Bian()   

  • Received:2021-02-01 Accepted:2021-03-29 Published:2021-05-06
  • Contact: Jiang Bian E-mail:bj@pku.edu.cn

摘要:

有机氟化物在很多领域(尤其是药物方面)有着广泛的应用,但鉴于氟的特殊反应性,氟原子的引入一直是有机化学中的难题。而有机电化学合成作为近年来新兴的合成手段,大大拓宽了有机反应的界限,使得更多绿色简易的氟化方法被开发了出来。本文就将集中列举这些有机电化学方法氟化的实例,并探讨电化学方法对于氟化学这一领域可能的推动作用。

关键词: 有机电化学, 氟化学, 有机合成, 方法学

Abstract:

Organic fluorides have been widely applied in various spheres, especially in the medical field. However, due to the distinctive reactivity of fluorine, the introduction of fluorine atom has always been a problem in organic chemistry. As a novel synthetic method developed in recent years, organic electrochemical synthesis has greatly expanded the boundaries of organic reactions, which have enabled the development of many efficient and eco-friendly fluorination methods. In this paper, we will focus on these examples of electro-chemical fluorination, and discuss the possible role of electrochemical methods in the field of fluoro-chemistry.

Key words: Electro-organic chemistry, Fluorochemistry, Organic synthesis, Methodology

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