大学化学 >> 2022, Vol. 37 >> Issue (3): 2105032.doi: 10.3866/PKU.DXHX202105032

化学实验 上一篇    下一篇

综合化学实验:5-溴-1-甲基芦竹碱衍生物的制备和表征

卢爱党(), 李林, 史绍洋, 姜艳军()   

  • 收稿日期:2021-05-17 录用日期:2021-06-15 发布日期:2021-06-17
  • 通讯作者: 卢爱党,姜艳军 E-mail:luaidang@hebut.edu.cn;yanjunjiang@hebut.edu.cn
  • 作者简介:姜艳军, Emails: yanjunjiang@hebut.edu.cn
    卢爱党, Emails: luaidang@hebut.edu.cn
  • 基金资助:
    河北省自然科学基金(B2020202028);河北省重点研发计划项目(21326504D);河北工业大学本科教育教学改革研究与实践项目(202003022);中国轻工业联合会教育工作分会课题(QGJY2020033)

A Comprehensive Chemical Experiment: Synthesis and Characterization of 5-Bromo-1-methylgramine Derivatives

Aidang Lu(), Lin Li, Shaoyang Shi, Yanjun Jiang()   

  • Received:2021-05-17 Accepted:2021-06-15 Published:2021-06-17
  • Contact: Aidang Lu,Yanjun Jiang E-mail:luaidang@hebut.edu.cn;yanjunjiang@hebut.edu.cn

摘要:

设计了题为“5-溴-1-甲基芦竹碱衍生物制备和表征”的综合实验,以5-溴吲哚为原料,经Hofmann烷基化反应和Mannich反应成功制备重要中间体5-溴-1-甲基芦竹碱,然后与不同的酸反应制备系列5-溴-1-甲基芦竹碱衍生物。结合化合物合成及表征,既能提高学生的综合实验能力,又能培养其对科学研究的兴趣和创新探索的精神。

关键词: 综合实验, 芦竹碱衍生物, Mannich反应, 成盐反应

Abstract:

The synthesis and characterization of 5-bromo-1-methylgramine derivatives has been designed for comprehensive chemistry laboratory. 5-Bromo-1-methylgramine is synthesized by Hofmann alkylation, Mannich reaction, and salification reaction from 5-bromoindole. Then, a series of derivatives were obtained by reacting with different inorganic or organic acids. Combined with synthesis, characterization and analysis of the target compounds, the comprehensive experiment can not only improve the students' laboratory ability, but also stimulate their interest in scientific research and the spirit of innovation and exploration.

Key words: Comprehensive experiment, Gramine derivatives, Mannich reaction, Salification reaction

MSC2000: 

  • G64