University Chemistry ›› 2016, Vol. 31 ›› Issue (6): 1-6.doi: 10.3866/PKU.DXHX201508003

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Carboxyl-Directed C―H Functionalization and Subsequent Decarboxylative Coupling Reactions of Aromatic Ac

Xian-Ying SHI*(),Ke-Yan LIU   

  • Published:2016-06-29
  • Contact: Xian-Ying SHI E-mail:shixy@snnu.edu.cn
  • Supported by:
    中央高校基本科研业务费专项资金项目(GK201503030)

Abstract:

Employing ortho or papa-substituted benzoic acids as starting materials, meta-substituted aromatic compounds, which are much more difficult to be prepared by the traditional methods, can be generated via an ortho C―H functionalization directed by carboxyl and subsequent ipso decarboxylation. In these reactions, carboxyl acts as the function of traceless-directing group. This paper reviews the recent progress in the transition-metal-catalyzed decarboxylative coupling reactions of aromatic acids to construct C―C and C―heteroatom bonds with carboxyl as the traceless-directing group.

Key words: Aromatic carboxylic acids, Decarboxylative coupling, Transition-metal-catalyzed, C―H Functionalization, Carboxyl-directing

MSC2000: 

  • O625.1