苯佐卡因的改进合成——推荐一个环保的多步合成实验

doi:10.3866/PKU.DXHX20160364

University Chemistry ›› 2016, Vol. 31 ›› Issue (3): 64-67.doi: 10.3866/PKU.DXHX20160364

• Chemistry Laboratory • Previous Articles Next Articles

Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step

Jin LIU*(),Kun WEI,Le CAI,Qiu-E CAO,Shi-Xi LIU

School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China

Published:2016-04-06
Contact: Jin LIU E-mail:liujin@yun.edu.cn
Supported by:
云南省质量工程教改项目(X311308)

Abstract

Abstract:

An improved synthesis of benzocaine is described. The synthetic route developed involves trichloroisocyanuric acid and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO) co-oxidation system as the key step. The method could avoid high toxicity, pollution, post-processing difficulties and other unfavorable environmental factors. The reactions were carried out under room temperature for short time with high yield and safe, easy, and environment-friendly operation.

Key words: Green chemistry, Benzocaine, Oxidation, Trichloroisocyanuric acid, TEMPO

MSC2000:

O6-31

Jin LIU,Kun WEI,Le CAI,Qiu-E CAO,Shi-Xi LIU. Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step[J].University Chemistry, 2016, 31(3): 64-67.

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Improved Synthesis of Benzocaine: A Proposal for an Environmentally Friendly Oxidation Method as the Key Step

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