University Chemistry ›› 2016, Vol. 31 ›› Issue (11): 67-71.doi: 10.3866/PKU.DXHX201604008

• Chemistry Laboratory • Previous Articles     Next Articles

Application of "Teaching One, Practicing Two, and Testing Three" in Organic Chemistry Laboratory Course: Taking Preparation of Benzoic Acid as an Example

Shuo LIU,Yu-Ping ZHAI,Jie HAN*()   

  • Published:2016-11-30
  • Contact: Jie HAN E-mail:hanjie@nankai.edu.cn
  • Supported by:
    南开大学2015年教学改革项目

Abstract:

The preparation of benzoic acid through the oxidation of toluene by KMnO4 was improved upon microwave irradiation in the presence of benzyl triethylammonium chloride.The reaction conditions such as microwave power, reaction temperature, reaction time, the molar ratio of reactants, and the dosage of catalyst were investigated.The results showed that the optimal reaction conditions were as follows:irradiation time 40 min, microwave power 80 W, reaction temperature 80℃, 0.2 equivalent of catalyst for toluene, and the molar ratio of KMnO4 to toluene to be 4.5:1.Compared with the traditional heating method, the microwave radiation shortened reaction time, and improved reaction efficiency up to 72.5% yield.Additionally, the preparation of benzoic acid was taken as an example to illustrate the application of the new method, namely, "teaching one, practicing two, and testing three" in organic chemistry laboratory course.

Key words: Benzoic acid, Microwave irradiation, Phase transfer catalyst, Teaching reform

MSC2000: 

  • G64