University Chemistry ›› 2016, Vol. 31 ›› Issue (4): 39-48.doi: 10.3866/PKU.DXHX20160439

• Survey of Chemistry • Previous Articles     Next Articles

Discussion and Classification of Cofactors Based on Their Chemical Essences and Functions

A. Zhipeng WANG1,2,Geng DENG1,*()   

  1. 1 Department of Chemistry, Tsinghua University, Beijing, 100086, P. R. China
    2 Department of Chemistry, Texas A & M University, Texas 77840, USA
  • Published:2016-05-06
  • Contact: Geng DENG E-mail:dengg13@mails.tsinghua.edu.cn

Abstract:

Cofactors are vital parts of proteins and enzymes, which play remarkably significant roles in the functional realization of enzyme catalyzing processes. However, in current study system of cofactors, the definition and classification are not clear enough. In this article, we suggest to divide the various cofactors into three major groups: catalysis-type cofactors, carrier-type cofactors, and substrate-type cofactors according to their chemical essences and catalytic mechanisms, followed by the discussion of several typical cofactor examples to demonstrate the specificity and regeneration of cofactors.

Key words: Cofactor, Coenzyme, Prosthetic group, Classification

MSC2000: 

  • O6