University Chemistry ›› 2018, Vol. 33 ›› Issue (3): 1-10.doi: 10.3866/PKU.DXHX201711038

• Chemistry Today • Previous Articles     Next Articles

Nuclear Medicine: The Synergy of Radiochemistry and Molecular Medicine

Cong LI2,Hui LIU1,Yuxiang HAN1,Zhibo LIU1,2,*()   

  1. 1 College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China
    2 Tsinghua University-Peking University Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, P. R. China
  • Received:2017-11-30 Published:2018-03-13
  • Contact: Zhibo LIU E-mail:zbliu@pku.edu.cn
  • Supported by:
    国家自然科学基金(21778003)

Abstract:

The major progresses of nuclear medicine since 1970s are briefly reviewed. This mini-review is mainly focused on the development of [18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG), which is the most widely applied PET tracer in clinic diagnosis. The investigation of [18F]FDG dated back to 1920s and was finally applied to the clinic after almost half century. [18F]FDG has been of great importance in the diagnosis of tumor, neurodegenerative diseases and cardiovascular diseases ever since. Except from [18F]FDG, the state-of-art development in peptide and protein nuclear medicines is also introduced. Along with the course of the development of nuclear medicine, several scientists who have made a great contribution to nuclear medicine are also introduced and paid at the same time with our sincere respect. With these introductions above, the authors intend to demonstrate the unique characteristic of nuclear medicine based on basic research and oriented to clinic problems. At last, the authors sincerely hope that the readers could be inspired on their own scientific researches after getting an insight into the history of classic nuclear medicines.

Key words: Nuclear medicine, Positron emission tomography imaging, Applied chemistry

MSC2000: 

  • G64