University Chemistry ›› 2018, Vol. 33 ›› Issue (7): 43-55.doi: 10.3866/PKU.DXHX201803060

Special Issue: 化学科普

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Past and Present of Nimodipine as Hypotensor

Hui ZHANG*()   

  • Received:2018-03-28 Published:2018-07-17
  • Contact: Hui ZHANG E-mail:huizhang@xmu.edu.cn
  • Supported by:
    国家基础科学人才培养基金(J1310024);国家自然科学基金(21273175)

Abstract:

Following the discovery and application of 1, 4-dihydropyridines nimodipine as the antihypertensive drug, this article briefly reviews the development of stereochemistry in Europe since the middle of the 19th century. Chemical stories are introduced, involving the invention of Hantzsch esters, close relationship between Hantzsch and his outstanding student-the founder of Coordination Chemistry-Werner, and Werner's pioneering contribution to chiral stereochemistry. An up-to-date introduction is given for the spontaneous resolution of racemic nimodipine under chiral crystallization and its precise characterization. Moreover, polymorphism and polymorphic drugs have been also described.

Key words: Chiral stereochemistry, Hantzsch reaction, Hypotensor, Polymorphism, Spontaneous resolution

MSC2000: 

  • G64