University Chemistry ›› 2019, Vol. 34 ›› Issue (5): 51-56.doi: 10.3866/PKU.DXHX201810009

• Chemistry Laboratory • Previous Articles     Next Articles

Continuous Synthesis of (E)Benzalacetonein Microchannel Reactor: An Introduction of a Comprehensive Chemical Experiment

Wanmei LI*()   

  • Received:2018-10-10 Accepted:2018-11-20 Published:2018-12-03
  • Contact: Wanmei LI E-mail:liwanmei@hznu.edu.cn
  • Supported by:
    杭州师范大学攀登工程二期学科建设项目;杭州师范大学教学改革研究项目;杭州市社会发展科研自主申报项目(20170533B02);浙江省教学改革研究项目(kg20160364)

Abstract:

Micro-reaction is an emerging technology that has been developing rapidly in recent years in all research fields of chemistry. In this experiment, benzaldehyde and acetone were used as the starting materials, thus (E)benzalacetone was continuously synthesized by condensation reaction in the presence of sodium hydroxide. By investigating effects of mole ratio, residence time and reaction temperature, the optimized reaction conditions were determined. The product was characterized by NMR and MS. Compared with traditional batch synthetic methods, the presented method has the advantages of high yield, simple operation, and reproducible experimental results. This work gives advanced technology and ideas in laboratory teaching, which not only enhances students' experimental skills, but also helps students to understand the frontiers of science, research situation, tendency of development and application prospects, as well as inspire students' interest greatly.

Key words: (E)Benzalacetone, Microchannel reactor, Continuous synthesis, Comprehensive experiment

MSC2000: 

  • G64