University Chemistry ›› 2019, Vol. 34 ›› Issue (9): 106-109.doi: 10.3866/PKU.DXHX201902003

• Chemistry Laboratory • Previous Articles     Next Articles

Examples of 1H NMR Spectra of Mixture of Compounds Containing Vicinal and Long-Range Fluorine-Proton Coupling

Yan HUANG,Jianglin WU,Zhenguo PANG,Zhiyun LU*()   

  • Received:2019-02-14 Accepted:2019-08-27 Published:2019-08-29
  • Contact: Zhiyun LU
  • Supported by:


Two serials of tetrasubstituted benzene compounds containing fluoro group were designed and synthesized. The other three substitutes are sequentially the para, meta, and ortho to fluoro group. The obtained compounds were all mixtures as confirmed by 1H NMR spectroscopies. The spectra clearly show the proximity and remote interaction between fluorine atom and hydrogen atom. In addition, the two spectra, one showing the overlapping peaks, one not, can be used as the simple and typical example of 1H NMR spectra of mixtures.

Key words: 1H NMR spectroscopy, Fluorine, H-F coupling, 1H NMR spectra of mixtures, Multiple substituent benzene


  • G64