University Chemistry ›› 2020, Vol. 35 ›› Issue (3): 76-81.doi: 10.3866/PKU.DXHX201907004

• Chemistry Laboratory • Previous Articles     Next Articles

Synthesis and Structural Characterization of Two Types of Chromene Derivatives Containing Pyrazolone or Indol-2-one: Reaction and Chemoselectivity of Carbonyl and Aldehyde Groups

Xuange Zhang1,Tianyu Lu1,Yan Cai1,Zihong Yan2,Zhiwei Miao1,2,*()   

  1. 1 State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China
    2 College of Chemistry and Environmental Sciences, Kashgar University, Kashgar 844006, Xinjiang Uygur Autonomous Region, P. R. China
  • Received:2019-07-02 Accepted:2019-09-28 Published:2019-10-29
  • Contact: Zhiwei Miao
  • Supported by:


Under the catalytic conditions of tetrahydropyrrole, an addition-elimination reaction of chromone aldehyde with methylpyrazolone or 2-indolinone is carried out to obtain two kinds of chromene derivatives containing pyrazolone or indol-2-one. The structures are identified by 1H NMR, 13C NMR, HPLC, HRMS and melting point measurements.

Key words: Pyrazolone chroman derivative, Indolinone chroman derivatives, Synthesis, Structural characterization


  • G64