University Chemistry ›› 2020, Vol. 35 ›› Issue (12): 35-43.doi: 10.3866/PKU.DXHX202004127

Special Issue: 科学抗疫中的化学

• Special Subject • Previous Articles     Next Articles

Application of Phosphoramidate Prodrugs Strategies and ProTide Technology in Anti-Virus Drug Discovery

Xiaobin Sun, Zhiwei Miao()   

  • Received:2020-04-30 Accepted:2020-07-04 Published:2020-07-08
  • Contact: Zhiwei Miao E-mail:miaozhiwei@nankai.edu.cn

Abstract:

Antiviral drug is a powerful weapon for humans to defeat the virus. The spread of 2019 novel coronavirus pneumonia (COVID-19) outbreak has a serious impact on the world. At the same time, it also makes people aware of the importance of antiviral drug development. This article reviews the application of the phosphoramidate prodrug strategy and the application of ProTide technology in the development of antiviral drugs. The synthesis methods of nucleoside-phosphoramidate prodrugs are introduced. The application of nucleoside-phosphoramidate in different antiviral drugs is also summarized. This review can provide a reference for the development of new antiviral drugs in the future.

Key words: Anti-virus drug discovery, Nucleoside-phosphoramidate prodrugs, ProTide technology

MSC2000: 

  • G64