(2R, 3R)-1, 4-二甲氧基-1, 1, 4, 4-四苯基-2, 3-丁二醇合成方法研究进展

doi:10.3866/PKU.DXHX202005074

Abstract

Abstract:

(2R, 3R)-1, 4-dimethoxy-1, 1, 4, 4-tetraphenylbutane-2, 3-diol has diverse applications in asymmetric organic synthesis, and this paper briefly introduces the progress on its synthetic methods from the perspective of green chemistry. Our group developed new synthetic methods based on the region-selective transformation of (2R, 3R)-1, 1, 4, 4-tetraphenylbutanetetraol. In the preparation, methanol was used as a methylating reagent and common inorganic alkali liquor was used instead of DDQ and LiAlH₄.

Key words: (2R, 3R)-1, 4-dimethoxy-1, 1, 4, 4-tetraphenylbutane-2, 3-diol, (2R, 3R)-1, 1, 4, 4-tetraphenylbutanetetraol, Region-selective reaction

MSC2000:

Xiaoyun Hu, Zixing Shan. Progress on the Study on Synthetic Method of (2R, 3R)-1, 4-Dimethoxy-1, 1, 4, 4-Tetraphenylbutane-2, 3-Diol[J].University Chemistry, 2021, 36(4): 2005074.

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References 9

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Progress on the Study on Synthetic Method of (2R, 3R)-1, 4-Dimethoxy-1, 1, 4, 4-Tetraphenylbutane-2, 3-Diol

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