University Chemistry ›› 2021, Vol. 36 ›› Issue (12): 2103014.doi: 10.3866/PKU.DXHX202103014

• Chemistry Laboratory • Previous Articles     Next Articles

Synthesis of Phenacetin and Principal Component Analysis of Compound Aspirin: An Organic Chemistry Experiment

Shui Hu1, Rong Lai1, Houjin Li1, Kejia Zhu1, Lei Zhou1, Guang Shao1,2,*()   

  1. 1 School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
    2 School of Chemistry Engineering and Technology, Sun Yat-Sen University, Zhuhai 519082, Guangdong Province, China
  • Received:2021-03-08 Accepted:2021-05-03 Published:2021-05-12
  • Contact: Guang Shao E-mail:shaog@mail.sysu.edu.cn

Abstract:

First, p-phenetidine and acetic acid were used as starting materials, and then acetic anhydride was added through nucleophilic substitution reaction to obtain phenacetin. The structure was identified by 1H-NMR. The components of compound aspirin were analyzed by thin layer chromatography and high performance liquid chromatography, and then the relations and differences between the two chromatography techniques were discussed. This experiment covers the experimental skills such as reflux, centrifugation, recrystallization, NMR, thin layer chromatography and high performance liquid chromatography, and can help the undergraduates improve their analytical abilities.

Key words: Phenacetin, Compound aspirin, Thin layer chromatography, High performance liquid chromatography

MSC2000: 

  • G64