University Chemistry ›› 2022, Vol. 37 ›› Issue (3): 2105032.doi: 10.3866/PKU.DXHX202105032

• Chemistry Laboratory • Previous Articles     Next Articles

A Comprehensive Chemical Experiment: Synthesis and Characterization of 5-Bromo-1-methylgramine Derivatives

Aidang Lu(), Lin Li, Shaoyang Shi, Yanjun Jiang()   

  • Received:2021-05-17 Accepted:2021-06-15 Published:2021-06-17
  • Contact: Aidang Lu,Yanjun Jiang;


The synthesis and characterization of 5-bromo-1-methylgramine derivatives has been designed for comprehensive chemistry laboratory. 5-Bromo-1-methylgramine is synthesized by Hofmann alkylation, Mannich reaction, and salification reaction from 5-bromoindole. Then, a series of derivatives were obtained by reacting with different inorganic or organic acids. Combined with synthesis, characterization and analysis of the target compounds, the comprehensive experiment can not only improve the students' laboratory ability, but also stimulate their interest in scientific research and the spirit of innovation and exploration.

Key words: Comprehensive experiment, Gramine derivatives, Mannich reaction, Salification reaction


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