University Chemistry ›› 2022, Vol. 37 ›› Issue (12): 2106046.doi: 10.3866/PKU.DXHX202106046

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Application of Electronic Density Distribution Analysis in Organic Chemistry Teaching for Developing Organic Chemistry Thinking

Zhuping Xiao(), Qiuju Feng   

  • Received:2021-06-21 Accepted:2021-08-30 Published:2021-09-23
  • Contact: Zhuping Xiao


This paper described the application of electronic density distribution analysis in organic chemistry teaching. In detail, after students got hold of mechanisms of organic reactions, teacher guided students to explore organic reactions based on electronic density distribution analysis of the functional group, to achieve the fusion of isolated, numerous, and weak logical reactions with rules. A knowledge system was therefore formed on the basis of electronic density distribution analysis. For example, integration of the electrophilic/nucleophilic addition reactions of alkenes and nucleophilic addition reactions of aldehydes/ketones has been reached; integration of the electrophilic/nucleophilic substitution reactions on benzene ring/six-membered heteroaromatic ring and electrophilic substitution reactions on five-membered heteroaromatic ring has been reached. Teaching method based on the electronic density distribution analysis helps students to develop organic chemistry thinking. Students therefore found a general method to master organic reactions, significantly reducing students' burden of memory. In a word, electronic density distribution analysis shows a distinct advantage in improving the efficiency and interest of learning as well as the flexibility in knowledge applications.

Key words: Electronic density distribution analysis, Organic chemistry thinking, Teaching, Ionic reaction, Knowledge integration


  • G642.0