University Chemistry ›› 2022, Vol. 37 ›› Issue (7): 2109039.doi: 10.3866/PKU.DXHX202109039

• Chemistry Laboratory • Previous Articles     Next Articles

Synthesis and Characterization of 1-Methyl-2-phenylindolin Induced by UV light: A Comprehensive Organic Micro Chemistry Experiment Converted from NSFC Research

Bing Li, Xinxin Zhao, Wujiong Xia, Yunchen Du(), Xijiang Han()   

  • Received:2021-09-10 Accepted:2021-11-22 Published:2021-12-14
  • Contact: Yunchen Du,Xijiang Han E-mail:yunchendu@hit.edu.cn;hanxijiang@hit.edu.cn

Abstract:

Organic photochemical reactions have attracted significant attention in recent years. Compounds based on the skeleton of indoline heterocyclic rings have shown various biological activities, such as antifungal, pest control, and medicinal activities for metabolic diseases. In the research of NSFC, we developed a new environmentally friendly method to synthesize indoline derivatives. Based on the results obtained from an organic micro chemical experiment, the synthesis of 1-methyl-2-phenyl indoline with styrene and 2-iodo-N-methylaniline was proposed through [3 + 2] radical cyclization induced by light. By introducing the latest scientific research findings into experimental teaching, the content and level can be enriched, and thus, we can help students establish the concept of green chemistry and environmental awareness, as well as effectively expand their knowledge.

Key words: UV-light chemistry, Indoline, Green chemistry, Laboratory teaching

MSC2000: 

  • G64