University Chemistry ›› 2022, Vol. 37 ›› Issue (7): 2109049.doi: 10.3866/PKU.DXHX202109049

• Chemistry Laboratory • Previous Articles     Next Articles

Application of Photochemical Synthesis of Nitrone under Continuous Flow in Undergraduate Laboratory Teaching

Jun Xuan1,*(), Weiwei Jin2, Lei Li1, Xiao Lian1, Qiong Zhang1, Chenjiang Liu2,*()   

  1. 1 College of Chemistry & Chemical Engineering, Anhui University, Hefei 230601, China
    2 College of Chemistry, Xinjiang University, Urumqi 830046, China
  • Received:2021-09-16 Accepted:2021-10-19 Published:2021-12-09
  • Contact: Jun Xuan,Chenjiang Liu E-mail:xuanjun@ahu.edu.cn;pxylcj@126.com

Abstract:

This experiment is oriented by photochemical synthesis of nitrone, and applied to undergraduate laboratory teaching. The integration of continuous flow chemistry and organic photochemistry can effectively expand the scope of current undergraduate organic chemistry laboratory teaching and let students understand the frontier research hotspots and new synthetic technologies. The photochemical synthesis of nitrones was realized by capturing the photo-generated carbene intermediates with nitrosobenzene. The simple flow photochemical reactor is cheap and easy to build, which is suitable for undergraduates to use in the basic laboratory. Through this experiment, students can also get familiar with the operation of thin-layer analysis, column chromatography and related instruments in micro organic reaction, and apply the theoretical knowledge of nuclear magnetic resonance hydrogen spectrum/carbon spectrum to analyze the structural products, exercise students' active exploration spirit and comprehensive practical ability, and improve students' awareness of environmental protection.

Key words: Flow chemistry, Photo-chemistry, Nitrone, Undergraduate laboratory teaching

MSC2000: 

  • G64