Abstract:

This experiment is oriented by photochemical synthesis of nitrone, and applied to undergraduate laboratory teaching. The integration of continuous flow chemistry and organic photochemistry can effectively expand the scope of current undergraduate organic chemistry laboratory teaching and let students understand the frontier research hotspots and new synthetic technologies. The photochemical synthesis of nitrones was realized by capturing the photo-generated carbene intermediates with nitrosobenzene. The simple flow photochemical reactor is cheap and easy to build, which is suitable for undergraduates to use in the basic laboratory. Through this experiment, students can also get familiar with the operation of thin-layer analysis, column chromatography and related instruments in micro organic reaction, and apply the theoretical knowledge of nuclear magnetic resonance hydrogen spectrum/carbon spectrum to analyze the structural products, exercise students' active exploration spirit and comprehensive practical ability, and improve students' awareness of environmental protection.

Key words: Flow chemistry, Photo-chemistry, Nitrone, Undergraduate laboratory teaching