研究性与系统性相结合的有机合成实验教学实践

doi:10.3866/PKU.DXHX202109076

Abstract

Abstract:

To cultivate students' innovative ability and practical ability, as well as to help them comprehensively master the theoretical knowledge and experimental skills of organic synthesis experiments, teaching exploration and practice of combining research and systematicness in organic synthesis laboratories have been carried out. In the process of designing the curriculum and teaching, we should implement ideas, methods, and teaching reforms that are student-centric. From the viewpoint of enhancing teaching reforms, teaching methods, assessment methods, and other teaching links that explore research, science, and education integration should be combined with the actual classroom teaching, advocate heuristic, and inquiry teaching methods. The implementation of a research-oriented teaching mode effectively stimulated the enthusiasm of students' independent research-oriented learning, improved their comprehensive practical ability, and established a clear correlation between laboratory teaching and scientific research.

Key words: Organic chemistry experiment, Organic synthesis, Research-oriented experiment, Research-oriented teaching

MSC2000:

Zhanxiang Liu, Zhenjun Mao, Dongbei Shao, Minrui Qin, Guochun Lan, Huangju Cai, Huarong Zhao. Teaching Practice of Organic Synthesis Laboratory Course Based on the Combination of Research and Systematicness[J].University Chemistry, 2022, 37(2): 2109076.

Figures/Tables 1

References 10

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实验项目名称	实验内容	学时
1. 讲座。有机合成实验课程介绍及安全事项 2. 实验室仪器整理	实验室安全教育、课程讲座 Schlenk真空线安装学习、仪器整理	6
3. 荧光天然产物7-羟基-4-甲基香豆素的合成	绿色有机合成、多种方法合成产物、比较优缺点；荧光测试	6
4. 多组分反应合成托品酮；生物活性天然产物的合成	1) 多组分反应合成托品酮；2) pH计控制酸度，低温反应；3) 有气体产生反应的处理；4)减压升华	6
5. 活性锌参与的Reformatsky反应；活性锌参与的Blaise反应	掌握无水无氧操作，低温操作，无氧条件下样品转移	12
6. 手性联萘酚的合成	掌握过渡金属催化条件下酚类氧化偶联，了解分子识别原理及其在手性拆分中的应用，HPLC测定光学纯度，重结晶	12
7. 磷叶立德的制备及烯烃类化合物合成	掌握Wittig试剂的制备以及反应，NMR表征产物	6
8. 可见光促进的杂环化合物与芳基重氮盐的C-H芳基化反应	可见光和有机染料光敏剂促进的合成反应；有机合成中间体捕捉和机理研究	12
9. Suzuki反应	有机合成化学中构建C-C键的常用方法	6
10. Sonogshira反应或Heck反应	过渡金属催化的偶联反应，二选一	6
11. 自主研究型实验	指定目标化合物的多种方法合成	18
12. 考核	实验考核讲解探究性实验PPT	6

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Teaching Practice of Organic Synthesis Laboratory Course Based on the Combination of Research and Systematicness

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