University Chemistry ›› 2022, Vol. 37 ›› Issue (7): 2110063.doi: 10.3866/PKU.DXHX202110063

• Survey of Chemistry • Previous Articles     Next Articles

Visible Light Mediated C(sp3)-H Bond Functionalization

Shuai Chen, Yihan Gucheng, Chengjian Zhu, Jin Xie()   

  • Received:2021-10-22 Accepted:2021-11-26 Published:2021-12-17
  • Contact: Jin Xie


As the energy source for chemical reactions, visible light has many advantages, such as cleanliness, low lost, and energy saving. Compared with the traditional thermal reactions, the organic reactions by means of visible light photoredox catalysis have relatively lower activation energy, and thus can be carried out under mild conditions. In recent years, selective functionalization of C(sp3)-H bond has been esteemed as one of the most creative emerging synthetic strategies in organic synthesis. In this paper, we briefly introduced the general principle of visible light photoredox catalysis and discussed the recent achievements of C(sp3)-H functionalization reactions involving α-C(sp3)-H adjacent to heteroatoms, benzylic C(sp3)-H, allylic C(sp3)-H and unreactive C(sp3)-H bonds, providing a robust synthetic strategy for the late-stage functionalization of natural products and pharmaceuticals.

Key words: Visible light, C-H activation, Radical, Organic chemistry


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