University Chemistry ›› 2022, Vol. 37 ›› Issue (7): 2111010.doi: 10.3866/PKU.DXHX202111010

• Chemistry Laboratory • Previous Articles     Next Articles

Study on NMR Assisted Selective Oxidation of Fluorobenzyl Alcohol Catalyzed by Gold Nanoparticles

Bangyan Chen1, Xinyu Cheng1, Ti Zhou1, Lisen Sun1,2,*(), Yongmei Liu1,2,*()   

  1. 1 Chemistry Department, Fudan University, Shanghai 200433, China
    2 National Demonstration Center for Experimental Chemistry Education (Fudan University), Shanghai 200433, China
  • Received:2021-11-02 Accepted:2021-12-21 Published:2022-01-27
  • Contact: Lisen Sun,Yongmei Liu E-mail:lssun@fudan.edu.cn;ymliu@fudan.edu.cn

Abstract:

In this project, we innovatively redesigned the experiment "Determination of Catalytic Activity of Oxidation Gold Nanoparticles in Benzyl Alcohol Oxidation reaction". 19F NMR, which is widely used in scientific research, is introduced into the teaching experiment as a kinetic detection method. The reaction substrate was replaced by fluorobenzyl alcohol, and the reaction rate constant and activation energy of substituents at different positions were compared through team cooperation. During the experiment, students can learn the principle and practical operation of NMR, compare the effect of substituent on catalytic reaction, and have a deeper understanding of catalytic mechanism combined with the theoretical knowledge of organic chemistry. The project realizes the organic combination of the dynamics teaching of 19F NMR detection with the theoretical knowledge of organic chemistry and instrumental analysis technology, and cultivates the students' ability of active thinking and solving practical problems.

Key words: 19F NMR, Catalytic oxidation, Gold nanoparticles, Fluorobenzyl alcohol, Substituent effect

MSC2000: 

  • G64