Abstract:

The paper, according to the online measuring of aspirin synthesis process, employs the chemometrics method based on the subspace-angle transformations to realize the nondestructive quantification and the trend tracking of aspirin synthesis products. The quantitative relation is the angle value of Raman spectra between the reaction system and the pure aspirin. On the concept introducing for the process analysis technology (PAT) and teachers' research improvements into the laboratory class, the reform on laboratory teaching is implemented, which enables students to have a direct understanding of new technology. The benefits to students include the broadening of vision, and the improvement of the learn-interest, and the quality and ability of enhancing the innovation.

Key words: Aspirin, Process analysis technology (PAT), Emerging engineering education, Chemistry metrology and technology