University Chemistry ›› 2014, Vol. 29 ›› Issue (1): 1-10.doi: 10.3969/j.issn.1000-8438.2014.01.001

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Targeting Inhibition of DNA Topoisomerases by Antitumor Drugs

Qian Chen, Peng Zaili, Chao Hui   

  1. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, Guangdong Province, P. R. China
  • Published:2014-02-25

Abstract: DNA topoisomerases are ubiquitous enzymes in eukaryotic cell and prokaryotic cell. They are widely existing in the nucleus and playing a crucial role in cellular genetic processing, such as transcription,replication and gene expression. Recent studies show that, topoisomerases are over expressed in cancer cell and thus they have become the important targets for screening of antitumor drug.

Key words: DNA topoisomerase, DNA topoisomerase inhibitor, anticancer drug