University Chemistry ›› 2017, Vol. 32 ›› Issue (12): 41-47.doi: 10.3866/PKU.DXHX201708002

• Survey of Chemistry • Previous Articles     Next Articles

Brief Introduction of Structures and Discovery of Novel Lysine Post-Translational Modifications in Native Proteins

Zhipeng WANG1,2,*(),Nong-Yi CHENG3,Yan-Yu LIANG2,Xin-Yu MA1   

  1. 1 Chemistry Department, Texas A & M University, College Station, TX 77840, USA
    2 Chemistry Department, Tsinghua University, Beijing 100084, P. R. China
    3 Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA
  • Published:2017-12-19
  • Contact: Zhipeng WANG


An increasing amount of novel protein lysine post-translational modifications (PTMs) have been gradually discovered. These PTMs with a large structural diversity widely exist in human proteome, which play an important epigenetically regulatory function to the chromatin structure and gene expression. This manuscript will briefly summarize the discovery and structure properties of the lysine PTMs from a chemical point of view, which will further benefit to teaching and research.

Key words: Lysine, Post-translational modification, Proteome


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