University Chemistry ›› 2018, Vol. 33 ›› Issue (6): 26-32.doi: 10.3866/PKU.DXHX201712027

• Survey of Chemistry • Previous Articles     Next Articles

Ortho Lithiation and Lithium-Halogen Exchange of Aromatic Halide

Chengtang DU*(),Yubin ZHANG,Dongdong ZHAO,Jun ZHANG,Kai LI   

  • Received:2017-12-18 Published:2018-06-01
  • Contact: Chengtang DU


In this paper, the mechanism, influence factor and application examples for ortho lithiation reaction and lithium-halide exchange reaction of aromatic compounds were introduced. The similarities and differences between these two reaction are discussed, so that readers can well master and apply this two important synthesis methods.

Key words: Aromatic halide, Ortho lithiation, Lithium-halogen exchange, Mechanism research


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