University Chemistry ›› 2020, Vol. 35 ›› Issue (3): 82-88.doi: 10.3866/PKU.DXHX201907024

• Chemistry Laboratory • Previous Articles     Next Articles

Mechanisms Study of Ninhydrin Synthesis from Diethyl Phthalate

Man Zhang1,Junhao Zhou1,Yucheng Hua1,Xiangwei Ren1,2,3,Wentao Zhao1,2,3,Wandong Zhang1,2,3,*()   

  1. 1 School of Science, Tianjin University, Tianjin 300354, P. R. China
    2 National Demonstration Center for Experimental Chemistry & Chemical Engineering Education(Tianjin University), Tianjin 300354, P. R. China
    3 National Virtual Simulation Experimental Teaching Center for Chemistry & Chemical Engineering Education(Tianjin University); Tianjin 300354, P. R. China
  • Received:2019-07-20 Accepted:2019-10-17 Published:2019-10-30
  • Contact: Wandong Zhang


Ninhydrin was synthesized from diethyl benzene-1, 2-dicarboxylate via Claisen condensation, hydrolysis, decarboxylation, nitrosation, deoximation, reduction, oxidation reaction and the possible reaction mechanisms for every unit reactions are discussed.

Key words: 2, 2-Dihydroxyindane-1, 3-dione (Ninhydrin), Diethyl benzene-1, 2-dicarboxylate, Mechanism


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