磷酰胺酯前药策略及ProTide技术在抗病毒药物研发中的应用

doi:10.3866/PKU.DXHX202004127

Abstract

Abstract:

Antiviral drug is a powerful weapon for humans to defeat the virus. The spread of 2019 novel coronavirus pneumonia (COVID-19) outbreak has a serious impact on the world. At the same time, it also makes people aware of the importance of antiviral drug development. This article reviews the application of the phosphoramidate prodrug strategy and the application of ProTide technology in the development of antiviral drugs. The synthesis methods of nucleoside-phosphoramidate prodrugs are introduced. The application of nucleoside-phosphoramidate in different antiviral drugs is also summarized. This review can provide a reference for the development of new antiviral drugs in the future.

Key words: Anti-virus drug discovery, Nucleoside-phosphoramidate prodrugs, ProTide technology

MSC2000:

Xiaobin Sun, Zhiwei Miao. Application of Phosphoramidate Prodrugs Strategies and ProTide Technology in Anti-Virus Drug Discovery[J].University Chemistry, 2020, 35(12): 35-43.

Figures/Tables 14

References 21

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Application of Phosphoramidate Prodrugs Strategies and ProTide Technology in Anti-Virus Drug Discovery

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