University Chemistry ›› 2021, Vol. 36 ›› Issue (6): 2006075.doi: 10.3866/PKU.DXHX202006075

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Discussion on the Application of Novel Protein Post-Translational Modification Discovered by Mass Spectrometry in Chemistry and Biology Education

Zhipeng A. Wang1,2,3,*(), Xuan Zhang4, Ziliang Che5, Zhenxiong Jiang6, Xinyu Ma2   

  1. 1 Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    2 Department of Chemistry, Texas A & M University, College Station, TX 77840, USA
    3 Department of Chemistry, Tsinghua University, Beijing 100084, China
    4 School of Life Sciences, Tsinghua University, Beijing 100084, China
    5 Department of Mathematics, Harvard University, MA 02138, USA
    6 Department of Biology, Texas A & M University, College Station, TX 77840, USA
  • Received:2020-06-29 Accepted:2020-08-13 Published:2020-09-14
  • Contact: Zhipeng A. Wang E-mail:wzpchem1991@gmail.com

Abstract:

Rapid development of mass spectrum technology (MS) brings about its wide applications in many fields such as chemistry, material science and life sciences, and its application in biochemistry and chemical biology have been greatly expanding the knowledge of novel protein post-translation modification (PTM). This manuscript starts from the basic principles of mass spectrum and later elaborates the application of MS in discovering lysine post-translation modifications over histones as model proteins, showing a path incorporating fundamental organic chemistry and biochemistry knowledge into cutting-edge researches. By analyzing roles of mass spectrum throughout post-translation modification studies under different research logistics, this manuscript was aimed to help establishing a way of thinking that associates fundamental chemistry and biology education with practical applications for students.

Key words: Mass spectrum technology, MS/MS, PTM, Biochemistry

MSC2000: 

  • G64